Methotrexate rasuvo, otrexup is a selfinjectable solution used to treat psoriasis and rheumatoid arthritis. The product catalog provides you with a full listing of tevas brand and generic product lines. Methotrexate methotrexate pfizer medical information. Each ml contains methotrexate sodium equivalent to 25 mg. The lower abdomen, thighs and upper arms are easiest for injection. Methotrexate injection, usp isotonic liquid, contains preservative is available in 25 mgml, 2 ml 50 mg vials. Methotrexate injection, usp, isotonic liquid, preservative free, for single use only, is available in 10 mgml, 2 ml 20 mg vials and 25 mgml, 20 ml 500 mg, 40 ml 1 g and 100 ml 2. Methotrexate injection usp formulations which contain benzyl alcohol as preservative are contraindicated in neonates and for intrathecal. The preserved formulation contains benzyl alcohol and must not be used for intrathecal or high dose therapy. Otrexup, rasuvo, and reditrex are only for once a week use and is not to be used daily.
Pregnant women who have psoriasis or rheumatoid arthritis must not use methotrexate. Sulfadiazine diffuses into the cerebrospinal fluid. Avoid injecting into areas with scars or stretch marks. Methotrexate has caused birth defects and death in unborn babies. Accidental ingestion safe handling practices include preparing, transporting, administering, andor disposing of material wastes. In the case of subcutaneous methotrexate autoinjector pens, many people have noted they are relatively painfree to use. By the mid 1990s, studies indicated that methotrexate is also well absorbed when injected into the fatty layer just under the skin subcutaneous. If you want to use the same injection site, make sure it is not the same spot on the injection site area you used for a previous injection. Methotrexate tablets, usp contain an amount of methotrexate sodium equivalent. Otrexup is a singledose autoinjector containing a prescription medicine, methotrexate. Actemra subcutaneous formulation is not intended for. Guide for adult patients self administering methotrexate. Trexall fda prescribing information, side effects and uses. When a dose of 100 mgkg of body weight is given initially and followed by 50 mgkg every 6 hours, blood levels of free sulfadiazine are about 7 mg100ml.
Treatment of candidemia, acute disseminated candidiasis, candida peritonitis and abscesses in adult and pediatric patients 4 months of age and older see clinical studies 14. Make sure the needle does not come into contact with anything on the way to the skin 4. If you have any further questions, ask your doctor or pharmacist or. The vial can be used for more than one dose because it contains a preservative called benzyl alcohol to keep it clean sterile between uses. Vitamin b12 is distributed into the liver, bone marrow, and other tissues, including the placenta. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides cutaneous t cell lymphoma, and lung cancer. Information on methotrexate methotrexate is a slow acting drug, which reduces disease activity. Psoriasis patients previously treated with puva and to a lesser extent, methotrexate or other immunosuppressive agents, uvb, coal tar, or radiation therapy, are at an increased risk of developing. Each 20 mg and 1 g vial of lyophilized powder contains methotrexate sodium equivalent to 20 mg and 1 g methotrexate respectively. Dailymed methotrexate methotrexate sodium injection.
The catalog displays all strengths and sizes along with the description, imprint code, ndc and photo for each product. Neoral soft gelatin capsules cyclosporine capsules, usp. Methotrexate is a medicine that may be used to treat crohns disease, arthritis, psoriasis, and other skin conditions. Cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. This type of injection is much easier to do than the one into the muscle and is less painful as the needle is much thinner. It can be given by mouth or injection and is usually given once a week. Aminophylline dihydrate is approximately 79% of anhydrous theophylline by weight.
Although mtx is generally safe, intolerability may be an important cause of treatment discontinuation and often includes gastrointestinal gi adverse events aes 46. Leucovorin calcium for injection leucovorin calcium for injection is indicated for intravenous or intramuscular administration and is supplied as a sterile lyophilized powder. Methotrexate formulations with preservatives must not be used for highdose treatment or injected into the spine intrathecal. Methotrexate sodium for injection, lyophilized, preservative free, for single use only, is available in 20 mg and 1 gram vials. Serious infections leading to hospitalization or death including. If you have any further questions, ask your doctor or pharmacist.
Otrexup is a once weekly medication that 98% of ra patients studied agreed was easy to use. Highlights of prescribing information these highlights do not include all the information needed to use humira safely and effectively. Cimzia is provided in a package that contains everything required to reconstitute and inject the drug see how suppliedstorage and handling 16. Methotrexate has caused birth defects and death in. Methotrexate injection, usp 250 mg per 10 ml 25 mg per ml contains preservative.
At birth, the blood concentration of vitamin b12 imneonates is 3 to 5 times that of the mother. Treatment of candidemia, acute disseminated candidiasis. Once the needle is in place, release your pinch on the. Otrexup, rasuvo, and reditrex are folate analog metabolic inhibitors indicated for.
Methotrexate injection, usp is sterile and nonpyrogenic and may be given. You should not repeat injections into the same spot. Trexall methotrexate tablets usp, for oral administration, is available in 5 mg, 7. Each 25 mgml, 2 ml vial contains methotrexate sodium equivalent to 50 mg methotrexate, 0. Risk of serious infections see full prescribing information for complete boxed warning.
Shingrix is not indicated for prevention of primary varicella infection chickenpox. Methotrexate injection usp without preservative may be given by the intramuscular, intravenous as a bolus, intraarterial, intrathecal or intraventricular via ommaya reservoir into the cns routes. Methotrexate injection fda prescribing information, side. Aminophylline injection, usp is a sterile, nonpyrogenic solution of aminophylline in water for injection. Methotrexate formerly amethopterin is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. Also, autoinjector pens may be associated with reduced pain on injection.
Each vial contains either mitomycin 5 mg and mannitol 10 mg, or mitomycin 20 mg and mannitol 40 mg, or mitomycin 40 mg and mannitol 80 mg. Information for the user methotrexate 25 mgml injection read all of this leaflet carefully before you start using this medicine. Treat certain adults with severe, active rheumatoid arthritis, and children with active polyarticular juvenile idiopathic arthritis pjia, after treatment with other medicines including nonsteroidal antiinflammatory drugs nsaids. The best areas are shown in the image light blue areas. Do not inject into areas where the skin is tender, bruised, red, or hard. Other forms of methotrexate include oral tablets and solutions for injection. Methotrexate injection, usp is sterile and nonpyrogenic and may be given by the intramuscular, intravenous, or intraarterial route see dosage and administration. Vials of vinblastine sulfate for injection usp contain 10 mg. Here are some important features of the vials of methotrexate. If all or part of antares is sold or merged into another entity, the information we have about you may be transferred to a third party as part of that transaction. Mitomycin for injection is a sterile dry mixture of mitomycin and mannitol, which, when reconstituted with sterile water for injection, provides a solution for intravenous administration. Information for the user methotrexate 25 mgml solution for injection methotrexate read all of this leaflet carefully before you start using this medicine because it contains important information for you. Finally, you and your doctor may prefer an autoinjector pen over a syringe and vial because it can deliver more accurate doses of methotrexate. Treat certain adults with severe, active rheumatoid arthritis, and children with active polyarticular juvenile idiopathic arthritis.
It is freely soluble in water, soluble in methanol, and slightly soluble in ethanol. Methotrexate injection usp formulations which contain benzyl alcohol as preservative are contraindicated in neonates and for intrathecal, intraventricular, or highdose therapy see contraindications. Methotrexate injection side effects, medical uses, and. Exposure to premixed, injectable methotrexate can occur by. Home otrexup methotrexate injection, for subcutaneous use.
Leucovorin may limit methotrexate action on normal cells by competing with methotrexate for the same transport processes into the cell. Methotrexate is also indicated in the treatment of meningeal leukemia. Do not inject into skin that is tender, damaged, or has bruises or scars. The clinical formulation is supplied in a sterile form for intravenous use only. Shingrix is a vaccine indicated for prevention of herpes zoster shingles in adults aged 50 years and older. For patients with inflammatory arthritis, methotrexate is supplied as 50 mg in a 2 ml vial 25 mg per 1 ml. Learn about side effects, warnings, dosage, and more. Each tablet contains methotrexate sodium in an amount equivalent to the labeled amount of methotrexate, usp, and contains the following inactive ingredients.
Leucovorin rescues bone marrow and gastrointestinal cells from methotrexate but has no apparent effect on preexisting methotrexate nephrotoxicity. It may take up to 3 months, during which time the dose may need to be adjusted, to have its full effect. Treat certain adults with severe, active rheumatoid arthritis, and children with active polyarticular juvenile idiopathic arthritis pjia, after treatment with other medicines including nonsteroidal antiinflammatory nsaids have. If your child has juvenile idiopathic arthritis jia, he or she may already be using injectable mtx.
Chemically methotrexate is n 4 2,4diamino6pteridinyl methylmethylaminobenzoyllglutamic acid. It is important to take methotrexate on the same day each week. Each 10 mgml, 2 ml vial contains methotrexate sodium equivalent to 20 mg methotrexate, and the following inactive ingredients. Women must avoid becoming pregnant while using this medication. The inactive ingredient is sodium chloride 140 mgvial for the 350 mg vial. Rasuvo methotrexate injection is a singledose autoinjector containing a prescription medicine, methotrexate. It prevents the growth of the white blood cells that cause inflammation. Methotrexate mtx has been a valuable treatment for rheumatoid arthritis ra for more than 30 years, and it remains the anchor drug for ra therapy.
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